Pharmacists can provide guidance in selecting appropriate drug therapies that are less likely to cause false readings, thus decreasing the need for additional testing. Unexpected results from urine immunoassays should have a confirmatory gas chromatography–mass spectrometry or a high-performance liquid chromatography test performed. By identifying medications that contribute to false-negatives and false-positives, pharmacists decrease misinterpretations from urine drug screens. False-negatives and false-positives from immunoassays can lead to adverse consequences for patients and providers. ABSTRACT: Urine drug screening is a common way to test for compliance with medications having high abuse potential.
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